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226 6 Nucleophilic Substitution Reactions on the Carboxyl Carbon dral intermediate forms irreversibly and consequently in the rate-determining step, a rate law for the formation of the SN product (Equation 6.
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Funding was generously provided by the National Science Foundation. As the internal concentration of KC is more than 10 times higher in the cell as compared to the extracellular space, the reversal potential E for KC channels is around ¡ 80 mV. Most of the rest of the energy is in the form of gamma rays. This means that a signal-to-noise ratio (SNR) for a brown noise contaminated ECG (such as movement artifact) equates to a much cleaner ECG than the same SNR for an ECG contaminated by pink noise (typical for observation noise).
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